职称：副教授

学历：博士研究生

电子邮件：qushuai@pku.edu.cn

研究方向：基因治疗；脂质纳米颗粒（LNP）；超声介导的药物递送

研究生招生专业：生物医学工程（学硕）、生物技术与工程（专硕）

教育工作经历：

2024.08-至今：yl9193永利官网，yl9193永利官网，副教授

2018.09-2024.07：北京大学，生物医学工程专业，博士研究生

2014.09-2018.07：哈尔滨工业大学，生物工程专业，本科

科研简介：

专注于开发高效、特异的体内基因递送策略。通过筛选优化脂质纳米粒（LNP）及设计优化mRNA序列，使其能够联合超声靶向微泡空化实现靶向体内特定组织器官乃至特定类群细胞递送mRNA，同时屏蔽外源mRNA在非超声辐照部位的表达，实现体内定点的基因表达乃至基因编辑，用于治疗动脉粥样硬化、癌症等疾病。

其他：光动力疗法（PDT）

代表性论文：

[1] Qu, S^#., Liu, R^#., Zhang, N., Xu, Y., Yue, X., & Dai, Z. (2022). Non-viral nucleic acid therapeutics: Revolutionizing the landscape of atherosclerotic treatment. Nano Today, 45, 101514.

[2] Liu, R^#., Qu, S^#., Xu, Y., Jo, H., & Dai, Z. (2022). Spatial control of robust transgene expression in mouse artery endothelium under ultrasound guidance. Signal Transduction and Targeted Therapy, 7(1), 225.

[3] Qu, S., Liu, R., & Dai, Z. (2022). Imaging-guided gene delivery: seeing is delivering. Journal of Bio-X Research, 5(04), 143-144.

[4] Xin, Z., Qu, S., Qu, Y., Xu, Y., Liu, R., Sun, D., & Dai, Z. (2024). Emerging IL-12-based nanomedicine for cancer therapy. Nano Today, 57, 102331.

[5] Liu, R^#., Yang, H^#., Qu, S., Yang, P., Zhi, X., Xu, Y., Dai, Z., Qian, L (2023). Photodynamic eradication of intratumoral microbiota with bacteria-targeted micelles overcomes gemcitabine resistance of pancreatic cancer. Aggregate, 00, e423.

[6] Liu, R., Xu, Y., Qu, S., & Dai, Z. (2023). Major Strategies for Spatial Control of Ultrasound-Driven Gene Expression to Enhance Therapeutic Specificity. Critical Reviews™ in Biomedical Engineering, 51(1).

[7] Xu, Y., Liu, R., Yang, H., Qu, S., Qian, L., & Dai, Z. (2022). Enhancing Photodynamic Therapy Efficacy Against Cancer Metastasis by Ultrasound-Mediated Oxygen Microbubble Destruction to Boost Tumor-Targeted Delivery of Oxygen and Renal-Clearable Photosensitizer Micelles. ACS Applied Materials & Interfaces.

[8] Liu, R., Xu, Y., Zhang, N., Qu, S., Zeng, W., Li, R., & Dai, Z. (2022). Nanotechnology for Enhancing Medical Imaging. In: Gu, N. (eds) Nanomedicine. Micro/Nano Technologies. Springer, Singapore.

[9] Liu, W., Han, F., Qu, S., Yao, Y., Zhao, J., Akhtar, M. L., ... & Li, Y. (2018). MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development. Cell death & disease, 9(10), 1-17.

[10] Li, K^#., Qu, S^#., Chen, X., Wu, Q., & Shi, M. (2017). Promising targets for cancer immunotherapy: TLRs, RLRs, and STING-mediated innate immune pathways. International journal of molecular sciences, 18(2), 404.

获奖情况：

北京大学优秀毕业生，2024